Our previous single-cell RNA sequencing study revealed that monocytes from patients with severe COVID-19 exhibit increased type I interferon (IFN) response in addition to tumor necrosis factor (TNF)/interleukin (IL)-1β–driven inflammation7; by contrast, others reported that severe COVID-19 was associated with impaired type I IFN response with an excessive release of TNF-α and IL-6.8 The gene discussed is TNF; the disease is COVID-19.