The 4C-DAS28 is a composite score of a 28 swollen and tender joint count (SJC and TJC), a visual analogue score (VAS: 0–100mm) of patient global assessment of arthritis activity and an objective biochemical marker of inflammation erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP). The gene discussed is CRP; the disease is arthritic joint disease.