To determine the potential relationship between the nuclear matrix‐associated proteins (NMPs) and GBM malignant growth, we mapped the expression of NMPs in TCGA GBM and low‐grade glioma (LGG) databases, with consideration of tumor transcriptional subtype, IDH1/P53/PTEN mutation status, tumor grade, patient age, and performance status. Here, TP53 is linked to glioblastoma.