To determine the potential relationship between the nuclear matrix‐associated proteins (NMPs) and GBM malignant growth, we mapped the expression of NMPs in TCGA GBM and low‐grade glioma (LGG) databases, with consideration of tumor transcriptional subtype, IDH1/P53/PTEN mutation status, tumor grade, patient age, and performance status. The gene discussed is IDH1; the disease is glioblastoma.