To interrogate the functional significance of SATB2 expression in GBM malignant growth, we initially examined SATB2 expression pattern in several human GBM specimens and found that SATB2 is preferentially expressed in nuclei of glioma cells expressing the GSC markers SOX2 and OLIG2 (Fig 1A and B; Appendix Fig S2A). The gene discussed is SOX2; the disease is central nervous system cancer.