Several genes, including HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 gene (HPS1, OMIM 604982), lysosomal trafficking regulator gene (LYST, OMIM 606897), and myosin VA gene (MYO5A, OMIM 160777), are considered as the main candidate genes involved in the pathogenesis of syndromic OCA. Here, HPS1 is linked to oculocutaneous albinism.