It is reported that genetic deletion of PAK1 in mice significantly attenuates circulating IL‐6 and MCP‐1 levels in atherosclerosis‐prone apolipoprotein E‐deficient (ApoE‐/‐) mice,47 PAK1 was also found to induce the secretion of IL‐1β by activating caspase‐1 in macrophages,48 suggested the potential role of PAK1 in the regulation of inflammation.49, 50. Here, APOE is linked to atherosclerosis.