IL1B and atherosclerosis: It is reported that genetic deletion of PAK1 in mice significantly attenuates circulating IL‐6 and MCP‐1 levels in atherosclerosis‐prone apolipoprotein E‐deficient (ApoE‐/‐) mice,47 PAK1 was also found to induce the secretion of IL‐1β by activating caspase‐1 in macrophages,48 suggested the potential role of PAK1 in the regulation of inflammation.49, 50