In line with this, a potentially confounding factor worth noting is the accumulating evidence for the presence of cancer-associated genomic alterations (e.g., mutations in the p53 tumor suppressor gene) in the clonal hematopoiesis (CH)-derived cfDNA of both cancer patients (Hu et al. 2018) and healthy individuals that do not have cancer and likely never will develop cancer (Anglesio et al. 2017; Fernandez-Cuesta et al. 2016; Genovese et al. 2014; Gormally et al. 2006; Newman et al. 2016). This evidence concerns the gene TP53 and cancer.