GPT and Sepsis: In septic mice and wild-type, PCSK9 knockout (KO), and transgenic (Tg) mice overexpressing PCSK9 subjected to sham surgery or cecal ligation and puncture (CLP), overexpression of PCSK9 in mice exacerbated liver and kidney pathology, as well as plasma IL-6, alanine aminotransferase (ALT), and thrombin-antithrombin (TAT) concentrations during sepsis, whereas the PCSK9 KO mice exhibited reduced bacterial loads, lung and liver pathology, myeloperoxidase activity, and plasma level of IL-10 and cfDNA during CLP-induced sepsis [25].