Moreover, insulin-induced recurrent hypoglycemia (two episodes/day for two weeks) in STZ-induced diabetic rats led to an increase in malondialdehyde (MDA) levels (product of the oxidation of n-6 unsaturated fatty acids) and a reduction in aconitase activity, which is an indicator of oxidative stress in brain mitochondria [186]. Here, INS is linked to Hypoglycemia.