NOS3 and vascular disorder: Activation of PKC has several pathogenic results, by affecting the expression of endothelial nitric oxide synthase (e-NOS), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and plasminogen activator inhibitor-1 (PAI-1), all of which play a role in vascular disorders.