The extended duration of hypoglycemia in the study by Gogitidze Joy et al. resulted in a more remarkable rise in proinflammatory mediators, even though blood glucose levels were not as low as in the study by Wright et al. In another study, Ceriello et al. used 2-hour hyperglycemic and hypoglycemic clamps, with or without the concurrent infusion of GLP-1, and quantified markers of oxidative stress (plasma nitrotyrosine and plasma 8-iso-PGF2a) and markers of inflammation (soluble intercellular adhesion molecule-1 (sICAM-1) and IL-6) [189]. Here, IL6 is linked to Hypoglycemia.