NFKB1 and gestational diabetes: In this study, we cultured the human placenta trophoblast cell line in physiological and high glucose levels, respectively, transfected with miR-518d mimics and inhibitors, followed by the detections on the expression levels of PPARα, its downstream genes, inflammatory factors, and NF-κB pathway-related proteins to investigate the regulatory mechanisms of miR-518d on the development and progression of GDM through the PPARα-mediated NF-κB signalling pathway.