According to our research results and previous literature reports, we hypothesized that miR-425-5p affects the ubiquitination modification by regulating the expression of RNF11, which weakens the binding of RNF11 to E2 binding enzyme and E3 ubiquitination ligase, and then affects the malignant biological behavior of HCC by regulating TGF-β and EGFR signaling pathway. This evidence concerns the gene RNF11 and hepatocellular carcinoma.