For example, a meta-analysis suggested the risks for ER- (RR = 0.60), PR- (RR = 0.72), and ER-/PR- (RR = 0.61) BC were significantly decreased with higher adherence to a MD, whereas no associations were found for ER+, PR+, or ER+/PR+ tumors (26). The gene discussed is ESR1; the disease is breast cancer.