Four factors identified to be significantly relevant to the severity of COVID-19 were underlying diseases (X1), fast respiratory rate (>24 times/min) (X2), elevated C-reactive protein level (CRP > 10 mg/L) (X3), and elevated lactate dehydrogenase level (LDH > 250 U/L) (X4) (Table 2). This evidence concerns the gene CRP and COVID-19.