CD274 and cancer: Liu et al. (2016) found that the levels of DEK in the cancer tissues were significantly upregulated and correlated with the pathological stage, disease-free survival, and OS time in NSCLC. The Cox proportional hazard regression model showed that DEK expression was an independent risk factor that affected prognosis (Liu et al., 2016). In addition, Schmidt et al. (2015) found that the level of PD-L1 in NSCLC was associated with tumor classification, tumor enlargement, positive lymph node, and prognosis of patients who received adjuvant therapy.