This non-transgenic strain shows similar neuropathological features of neurodegenerative diseases such as AD, and encompasses Aβ alterations, increased oxidative stress, augmented tau phosphorylation, as well as learning and memory deficits (Butterfield and Poon, 2005; Pallas et al., 2008; Takeda, 2009; Morley et al., 2012). Here, MAPT is linked to Alzheimer disease.