Firstly, bone can be considered a fertile and productive soil due to its richness in growth factors and cytokines (e.g., TGF-β, IGF-1/2, BMPs, IL11, etc.)produced by osteoblasts, stored in bone matrix, and released during physiological bone disruption becoming bioavailable for cancer cells (Florencio-Silva et al., 2015; Owen and Parker, 2019). This evidence concerns the gene TGFB1 and cancer.