In this scenario the interplay generated by cytokines, proteases, growth factors and receptors (e.g., EGF signaling, TGFβ, RANK-RANKL, OPG, MMPs etc.)gives rise to the so-called “vicious cycle” that involves not only cancer cells but also non-neoplastic bone cells (osteoblasts, osteoclasts, osteocytes) contributing to the break of bone homeostasis (Weilbaecher et al., 2011; Arrigoni et al., 2016; Yu and Hoffe, 2018; Dewulf et al., 2019). This evidence concerns the gene TGFB1 and cancer.