IL1B and ocular melanoma: After 21 days of culture, BM-MSCs cultured in OM appeared to have similar levels of mineral deposition compared to BM-MSCs transfected with PEI-pIL-1Ra nanoparticles cultured in OM + IL-1β, while non-transfected BM-MSCs cultured in OM + IL-1β and BM-MSCs transfected with PEI-pGFP cultured in OM + IL-1β showed markedly less mineral deposition (Figure 5C).