Similarly, the expression of Ibsp in BM-MSCs transfected with PEI-pIL-1Ra, cultured in OM + IL-1β, was significantly higher to the expression of Ibsp in BM-MSCs cultured in OM + IL-1β after 14 days in culture (p < 0.0001) (Figure 4B). This evidence concerns the gene IL1B and ocular melanoma.