SCAP and neoplasm: TGFβ1 has been reported to activate the sterol regulatory element-binding protein 2 (SREBP2) in kidney mesangial cells, and SREBF2 activation was dependent on sterol regulatory element-binding protein cleavage-activating protein (SCAP) (11, 12), inhibition of SCAP or SREBPs significantly suppressed tumor growth in various cancer (13).