An osteomimicry profile is characterized by an increased expression of bone sialoprotein (BSP), osteopontin (OPN), osteoprotegerin (OPG), osteonectin (ON), cadherin 11 (CDH11), transcription factor runt-related transcription factor 2 (Runx2) (96), etc. These bone-related genes (BRGs) are highly expressed in bone metastatic cancer cells, compared to those cells metastasized in other organs, and their expression is regulated by the transcription factor Runx2 that acts as a master mediator (97). The gene discussed is SPP1; the disease is cancer.