WFDC2 and congenital rubella syndrome: Table 2 lists the AUC, optimal cut-off values, sensitivity, specificity, and Youden indices of post-NACT CA125, percent decrease in CA125, post-NACT HE4, and percent decrease in HE4 (HE4 Pre-NACT—HE4 Post-NACT/HE4 Pre-NACT) for predicting CRS 3 following NACT, and Figures 1A–D shows the ROC curves.