It has been hypothesized that the angiogenic phenotype may result from the production of various growth factors, such as fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) by the tumor cells and/or the down-regula­tion of negative modulators, like thrombospondin-1 (TSP-1) in tissues with dormant vasculature [6-7] However, very few studies were performed over the years to understand the nature of the MC in the tumor angiogenesis and progression. This evidence concerns the gene THBS1 and neoplasm.