The aim of the current study was firstly, to assay the IL-6 mRNA Levels in the atherosclerosis patients’ peripheral blood, secondly, to examine the methylation status of IL-6 promoter in atherosclerosis patients who are candidate for coronary artery bypass grafting surgery, and finally to evaluate the relationship between methylation status of CpG motifs in IL-6 gene promoter and IL-6 mRNA levels in these patients. The gene discussed is IL6; the disease is atherosclerosis.