IL-6, together with growth factor (TGF) -β, plays an important role in the differentiation of Th17 cells from naive CD4 + T cells.15,18,19 Naive T CD4+ cell precursors are generated Tfh and they participate in antigen-specific B lymphocytes differentiation into memory and plasma cells.15,20 Among atherosclerosis patients, the response of systemic inflammatory variability can be explained by different patterns of epigenetic changes that alter the expression of genes involved in the process of the atherosclerotic process. The gene discussed is IL6; the disease is atherosclerosis.