A prior clinical study revealed a significant relationship between lower serum albumin levels and adverse cardiovascular outcomes in subjects with acute myocardial infarction.18 Also, it has been demonstrated that lower serum albumin levels are related to coronary ISR.5 In terms of the PAD spectrum, Ishii et al found that lower albumin levels could strongly predict major adverse limb events, including target vessel revascularization and amputation.19 The gene discussed is ALB; the disease is acute myocardial infarction.