ENPP1 and arterial calcification, generalized, of infancy, 1: Idiopathic infantile arterial calcification or generalized arterial calcification of infancy (GACI, OMIM 208000) is a heritable, rare autosomal recessive condition, characterized by extensive calcification of medium and large arteries such as renal arteries, aorta, and coronary arteries that is resulted from loss of function mutations in ecto-nucleotide pyrophosphatase/phosphodiesterase1 (ENPP1) gene.