PPARG and heart failure: Indeed, changes in endothelial permeability and vascular leakage could contribute to drug-induced progression of heart failure and peripheral oedema, and such detrimental mechanism in diabetic patients was reported for rosiglitazone [28], a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, shown to significantly increase the risk of heart failure [29].