Although the exercise training was able to decrease the systemic VEGF levels in the trained mice group with IPF (Bleo+Exe) compared to nontrained mice group with IPF (Bleo), higher levels of TGF-β, IGF-1 and VEGF, both in serum and BAL of the IPF mice, can support our findings that the percentage of collagen deposition in the parenchyma and also the pulmonary mechanics parameters were unchanged in these experimental groups. This evidence concerns the gene IGF1 and idiopathic pulmonary fibrosis.