In the univariate analysis, LDH (χ2 = 5.515; P = 0.019), β2-M (χ2 = 11.232; P = 0.001), IPI scores (χ2 = 15.672; P = 0.000), B symptom (χ2= 8.660; P = 0.003), DEL (χ2 = 4.439; P = 0.035), high sPD-L1 level (χ2 = 13.708; P = 0.000), high STAT3 level (χ2 = 9.780; P = 0.002) were associated with poor prognosis in patients with DLBCL. Here, STAT3 is linked to diffuse large B-cell lymphoma.