For example, IRD800CW labeled CD30 aptamer is used for in vivo imaging of lymphoma 115, Cy5 labeled pancreatic cancer-specific aptamer is used for in vivo imaging of pancreatic cancer 116, AS1411 aptamer coupled with blood-brain barrier targeting peptide for in vivo imaging of gliomas 117), etc. All of them show fast and specific tumor targeting ability, high signal-to-noise ratio and good pharmacokinetic properties. Here, TNFRSF8 is linked to pancreatic neoplasm.