Given the evidence of the close correlation between NIS downregulation and the dedifferentiation of ATCs and the ability of Res to promote ATC cell differentiation, it would be possible that NIS expression will be elevated and NIS proteins may re-appear on the membrane of Res-treated ATC cells as what is happened to E-cadherin 20. Here, CDH1 is linked to Ehlers-Danlos syndrome, musculocontractural type.