The observed decrease in luciferase activities meant an increased binding capacity of miR-27a-3p, thereby affecting the expression of CTNNBIP1. Furthermore, from the TCGA and Oncomine databases, we found that CTNNBIP1 might act as a chemosensitivity-related gene due to its relatively higher expression levels in chemosensitive ovarian cancer serious histology, compared with other types of histology. Here, CTNNBIP1 is linked to ovarian carcinoma.