HINT1 and cancer: Based on the normalized TCGA RNA-Seq data, we found that among the candidate target genes, the expression of HINT1, CDC42SE2 and FNIP1 differed between the cancer tissues and the normal tissues (P-value = 0.0172, P-value <0.0001 and P-value <0.0001, respectively, shown in Supplementary Fig S2), however, in the TCGA data, tumor and normal tissues data are not paired.