Because we are committed to renal clear cell carcinoma research, and to explore the potential biological role of these target genes in tumors, we targeted the five SUMOylation regulators (PIAS1, PIAS3, SENP8, SUMO4, and TRIM27) that were present in the risk signature of KIRC upon gene-set enrichment analysis (GSEA) 16. Here, PIAS1 is linked to clear cell renal carcinoma.