CCL20 and pachyonychia congenita: Serum CCL20 exhibited the sensitivity of 72.4% and specificity of 93.5% to distinguish PC, Further, we showed that preoperative serum CCL20 level was significantly associated with clinicopathological characteristics including T stage, nodal status, and pelvic LNM in PC; high preoperative serum CCL20 level could serve as an independent prognostic factor for unfavorable disease free survival in PC.