In summary, this study demonstrated the TNF + N group has a similar survival outcome and less grade 3/4 vomiting than the TPF + P group, suggesting that the TNF regimen followed by CCRT with nedaplatin is an alternative treatment strategy to the standard TPF regimen followed by CCRT with cisplatin for patients with locoregional advanced NPC. The gene discussed is TNF; the disease is nasopharyngeal carcinoma.