TCR repertoire overlap between a terminally exhausted TIL population, characterized by high expression of coinhibitory receptor genes, and a predysfunctional TIL population, characterized by expression of GZMK, was also found in human melanoma (64), NSCLC (60), colorectal cancer (CRC) (80) and hepatocellular carcinoma (HCC) (65). The gene discussed is GZMK; the disease is colorectal carcinoma.