Concurrently, obesity increases intratumoral CXCL1 concentrations, promoting CXCR2-mediated accumulation of FasL+ G-MDSCs, resulting in heightened Fas/FasL-mediated CD8 TIL apoptosis and immunotherapy resistance (Figure 7). The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.