Proteomic phenotypes revealed 68 upregulated and 74 downregulated proteins among 762 proteins identified in the comparison of RA patients with moderate to high disease activity and healthy subjects, and the most differentially expressed immune-/inflammation-related proteins were PLA2, CRP, SAA2, FGL1, ORM2, and PADI4. The gene discussed is FGL1; the disease is rheumatoid arthritis.