TGFβ, IL-10, and tumor-derived exosomes, which contain IL-10, TGFβ, IDO1, and PDL1/L2, are secreted from tumor cells and potentiate the differentiation of inhibitory Tregs, which is characterized by increased expression of FoxP3 and CTLA4 (22–24). This evidence concerns the gene IDO1 and neoplasm.