TGFβ, IL-10, and tumor-derived exosomes, which contain IL-10, TGFβ, IDO1, and PDL1/L2, are secreted from tumor cells and potentiate the differentiation of inhibitory Tregs, which is characterized by increased expression of FoxP3 and CTLA4 (22–24). Here, CTLA4 is linked to neoplasm.