CD274 and ovarian cancer: To conclude, the mechanisms of immunosuppressive networks of ovarian cancer include inhibition of CD8+ effector cells by Tregs, suppression of receptor PD-1 engaging by the ligand PD-L1; myeloid-derived suppressor cells and inhibitory cytokines (44).The immunosuppressive network is a significant obstacle in immunotherapy, which must be overcome to ensure the implementation of effective immunotherapeutic strategies.