Given that such inflammatory mediators as PGE2, IL-6, TNF-α, and GM-CSF promote the expansion and activation of MDSC's (227), the hyperactive immune response and cytokine storm described in SARS-CoV-2-infected patients has resulted in a handful of studies investigating whether MDSC's may contribute to the pathogenesis of COVID-19. The gene discussed is TNF; the disease is COVID-19.