Infection of Mφ and A549 cells induced cell death (LDH release-, MOI- and time-dependent)Lai (virulent) but not Patoc induced apoptosis (2–6 hpi) and later induced (> 12 hpi) necroptosis.Caspase-3, -6, -8, and -9 were activated upon infection with Lai but not with Patoc.Lai induced cleavage of PARP and Lamin A/C. FADD levels increased upon infection of Mφ. Induction of apoptosis was also observed in primary naive peritoneal Mφ. Here, CASP3 is linked to infection.