Notably, we have also highlighted the potential protective role of TLR2 in the human defense against Leptospira. Indeed, single nucleotide polymorphisms (SNPs) in TLR2 and TLR1, which are known to modulate susceptibility to infectious diseases, have been linked to increased susceptibility to developing severe leptospirosis in Argentina (124). Here, TLR2 is linked to leptospirosis.