Subcellular “lesions” upon infection with Lai (virulent) and Luo (avirulent) (EM).Surprisingly, Lai was occasionally associated with nuclei.Live and UV-killed Lai and Luo induced apoptosis (annexin V+/PI-) in Vero cells and necroptosis (annexin V+/PI+) in Mφ. Both live and UV-killed serovars produced a similar phenotype. The gene discussed is ANXA5; the disease is infection.