ROC curve analysis revealed that IgA–aCL and IgA–aβ2GPI have a similar diagnostic accuracy for APS, with AUCs of 0.670 (95%CI: 0.607–0.733, P < 0.001) and 0.654 (95%CI: 0.590–0.718, P < 0.001), respectively. Here, ACLY is linked to autoimmune polyendocrinopathy.