CD40LG and autoimmune polyendocrinopathy: According to the 2006 update of the International consensus statement on classification criteria for APS, the presence of lupus anticoagulant (LA) and/or the immunoglobulin (Ig) G and/or IgM isotypes of anticardiolipin antibodies (aCL) and/or anti-β2 glycoprotein-I (aβ2GPI) indicate APS (1).