CXCR2 is also expressed on airway smooth muscle cells (55, 56) and in this work we showed that CXCR2 may be a key feature in the development of airway hyperresponsiveness and, Ladarixin may be acting on CXCR2 expressed on ASM cells to improve the airways hyperresponsiveness. This evidence concerns the gene CXCR2 and airway hyperresponsiveness.