In this work we used a classic model of Th2 eosinophilic airway inflammation, and, an alternative model of Th17 neutrophilic airway inflammation in which mimics to GC-refractory asthma to better understand the role of CXCR1 and CXCR2 receptors in different manifestations of asthma. This evidence concerns the gene CXCR2 and asthma.