For instance, stimulation by recombinant soluble Schistosoma mansoni egg antigen (rSm29) could induce mono-DC with high expression of MHC-II and costimulatory molecules while rSm29 could increase IL-10 level and decrease levels of IL-12p40 and interferon-gamma (IFN-γ) in cultured mono-DC, which results in a great therapeutic efficacy on cutaneous leishmaniasis (32). This evidence concerns the gene IFNG and cutaneous leishmaniasis.