CD73 expression was significantly increased within the subset of CD133+CXCR4+ MICs (median value= 80%; min 14%, max 100%) compared to CD133+ CSCs (median= 44%; min 2%, max 95%) and bulk tumor (median= 46%; min 2.5%, max 65%) (Figure 1B). Here, CXCR4 is linked to neoplasm.