We also observed a down-regulation of HLA class I, antigen presenting molecule, in CD133+ CSC compared to tumor bulk population, both in NSCLC primary tumors (n=6) and NSCLC cell lines (n=4) (0,7 fold decrease compared to bulk cells) (Figures S1A, B), confirming the ability of CSC to escape immune cells recognition. The gene discussed is PROM1; the disease is neoplasm.