High levels of extracellular adenosine, generated by canonical CD39/CD73 or non-canonical CD38/CD73 adenosinergic pathways in tumor microenvironment (28, 29), can promote tumor progression by directly stimulating tumor proliferation, migration, invasion, and metastatic dissemination and by favoring immune escape of tumor cells (33). The gene discussed is ENTPD1; the disease is neoplasm.