Compared with those patients free of thyroiditis, the baseline anti-thyroglobulin antibodies (TgAbs) and anti-thyroid peroxidase antibodies (TPOAbs) levels were significantly higher in destructive thyroiditis patients (41), the appearance of thyroid dysfunction during PD-1 treatment closely associated with anti-thyroid antibodies (55). This evidence concerns the gene PDCD1 and thyroiditis.