The role of the EphA2 receptor in the transport of C. neoformans over the blood–brain barrier (Aaron et al., 2018) and the importance of EphA2 activation for the antifungal activity of neutrophils (Swidergall et al., 2019) highlights the important role of EhpA2 in fungal infections. The gene discussed is EPHA2; the disease is fungal infectious disease.