The dysregulation on this pathway alters PGC-1α (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha), SREBP-1c (Sterol Regulatory Element-Binding Transcription Factor 1), and NF-κB, enhancing obesity. Here, SREBF1 is linked to obesity due to melanocortin 4 receptor deficiency.