INS and obesity due to melanocortin 4 receptor deficiency: The miRNAs are strongly related to immune response dysfunctions in metabolic syndrome, as in macrophages polarization (104), adipogenesis regulators and mediators of the fatty acids metabolism, also contributing to adipocyte hypertrophy in obesity, hepatic steatosis, and lipid homeostasis disorders, insulin signaling pathways, β-pancreatic cells mass, and endocrine function (105).