Thus, an hs-CRP level ≥3 mg/L (OR: 37.16, 95% CI: 2.78–496.46, p = 0.006), age (OR: 1.25, 95% CI: 1.08–1.45, p = 0.003), baseline hematoma volume (OR: 1.07, 95% CI: 1.01–1.13, p = 0.03), and HE (OR: 18.12, 95% CI: 1.41–233.32, p = 0.03) were identified as significant and independent predictors for an unfavorable outcome 1 year after acute ICH (Table 3). The gene discussed is CRP; the disease is hereditary elliptocytosis.