CD4 and metabolic dysfunction-associated steatohepatitis: The observed changes in the T helper cell profile during NASH development can be caused either by a depolarization of CD4+ T cells to a TH17 cell phenotype, or by a relative shift of the CD4+ T cell composition in the liver due to depletion of other T helper cell subsets, or driven by an altered infiltration of distinct CD4+ T cell subsets.