Cel inhibited the translocation of NF-κβ p65 and reduced the phosphorylation of IKBα and IKK in FLSs from patients with RA, resulting in the decreased expression of several chemokines (i.e., CCR2, CXCR4, CCL2, CXCL10, and CXCL12), cytokines (i.e., IL-6, IL-8, and MCP-1), and matrix metalloproteinase-9 (MMP-9) (Fang et al., 2017). This evidence concerns the gene CCL2 and rheumatoid arthritis.