HIF1A and glomerular disorder: The involvement of dysregulation of hypoxia-associated mechanisms in GEnCs in the pathogenetic pathways leading to glomerular disease is further substantiated by a study showing that endothelial-specific knockout of hypoxia inducible factor 1α (HIF1α) prevents the development of proteinuria and collagen deposition in hypertensive FSGS (Luo et al., 2015).