Loss of endothelial hyaluronan and thereby the endothelial glycocalyx induced by an endothelial-specific deletion of the hyaluronan synthesis enzyme hyaluronan synthase 2 (HAS2) (van den Berg et al., 2019) or by treatment with the hyaluronan-degrading enzyme hyaluronidase (Meuwese et al., 2010) also induces proteinuria (Meuwese et al., 2010; van den Berg et al., 2019) and progressive glomerulopathy (van den Berg et al., 2019), phenocopying the events in DN. Here, HAS2 is linked to liver dysplastic nodule.