Also podocyte-specific VEGFA overexpression results in loss of GEnCs and collapse of capillary loops (Eremina et al., 2003) and causes advanced DN with endothelial swelling (Veron et al., 2011), suggesting the existence of a delicate balance between the protective and deleterious effects of VEGFA, depending on the strength of signaling. The gene discussed is VEGFA; the disease is liver dysplastic nodule.